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The total synthesis of complex molecules demands a thorough knowledge of reactions that form carbon-carbon bonds, as well as those that change one functional gr. The objective of wodca is to assist the organic chemist in each step of the synthesis planning process , compilation of the best free computational chemistry software. Kaff6, retrosynthesis 2001 (4) “retrosynthetic analysis” in other words, “retrosynthetic analysis (or antithetic analysis) is a problem-solving.